Obesity is a risk factor of coronary diseases, cancer, vascular brain disorders, and diabetes type II. The purpose of this work is to evaluate the capacity of valproic acid, trichostatin A and resveratrol agents in the reduction of fat accumulation in the adipocyte cell. Valproic acid and trichostatin A inhibit histone deacetilase activity type I and II, while resveratrol is a sirtuin 1 activator belonging to the family ...