Modelo Animal de Anemia Inducida por Flebotomía Crónica: Relación Funcional Entre Hierro y Eritropoyesis
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Castillo Bohórquez MSC, Martha
D´Anna, María
Gaona Prieto, Suani
García, Betina
Giorgi, Gisela
Mora Bautista MSC, Ana Isabel
Roque, Marta
Villarraga Muñoz, María del Mar
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Universidad Colegio Mayor de CundinamarcaCitación
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En el presente estudio se analizo la respuesta eritropoyética a la anemia inducida por flebotomía crónica y los cambios en la distribución del hierro celular y sistémico del organismo. Ratones hembra de la cepa CF1 (n=32), se dividieron en dos lotes: control y experimental, siguiendo un diseño experimental pareado según su peso. La distribución del hierro en bazo e hígado durante la flebotomía crónica fue evaluada mediante estudios morfológicos y la actividad eritropoyética mediante estudios hematológicos. Las diferencias estadísticas se determinaron mediante Test Student. El nivel de significancia se fijó en p In the present work we studied the erythropoietic response to chronic phlebotomy-induced anemia and changes in cellular and systemic body iron distribution. Female mice (CF1 strain, n =32) were divided into control and experimental groups, following a paired experimental design. Iron distribution in spleen and liver during chronic phlebotomy was assessed by morphological studies and erythropoietic activity by hematological studies. Statistical differences were determined by Student test. The significance level was set at p
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