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Title:	Analysis of the population of Foxp3 regulatory T cells in the murine model of intestinal amebiasis Análisis de la Población de Células T Reguladoras Foxp3 en el Modelo Murino de Amibiasis Intestinal
metadata.dc.creator:	Cruz B., Claudia Andrea Laclette, Juan Pedro Sarrazola S., Mauricio
Keywords:	Ciencias Médicas y de la Salud,Ciencias de la Salud,Parasitología;amibiasis; células Treg; Entamoeba histolytica; esplenocitos trofozoítos.;amebiasis; Treg cells; Entamoeba histolytica; splenocytes trophozoites.
Publisher:	Universidad Colegio Mayor de Cundinamarca
metadata.dc.relation:	http://hemeroteca.unad.edu.co/index.php/nova/article/view/435/1108 /*ref*/Walsh JA. Problems in recognition and diagnosis of amebiasis: estimation of the global magnitud of morbidity and mortality. Rev Infec Dis. 1986;8:228-238. 2. Ortiz-Ortiz L, Zamacona G, Sepúlveda B, Capín NR. Cell-mediated immunity in patients with amebic abscess of the liver. Clin Immunol Immunopathol. 1975;4:127-34. 3. Ghosh PK, Castellanos-Barba C, Ortiz-Ortiz L. Intestinal amebiasis: cycli suppression of the immune response. Parasitol Res. 1995;81: 475-480. 4. GHOSH P., et al. Experimental Amebiasis: Immunohistochemical Study of Immune Cells Populations. J. Eukaryot. Microbiol. 2000;47:395-399. 5. Maloy, K. J., and Powrie, F. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2001;.2:816–822. 6. Sakaguchi S, Sakaguchi N, Shimizu J, Yamazaki S, Sakihama T, Itoh M, Kuniyasu Y, Nomura T, Toda M, Takahashi T. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 2001;182:18–32. 7. Gavin, M., and Rudensky, A. Control of immune homeostasis by naturally arising regulatory CD4+ T cells. Curr. Opin. Immunol. 2003;15:690–696. 8. Belkaid, Y., Blank, RB., Suffia, J.. Natural regulatory T cells and parasites: a common quest for host homeostasis. Immunol Rev Review. 2006; 212:287-300. 9. Hisaeda H, Hamano S, Mitoma-Obata C, Tetsutani K, Imai T, Waldmann H, Himeno K, Yasutomo K. Resistance of regulatory T cells to glucocorticoid-viduced TNFR family-related protein (GITR) during Plasmodium yoelii infection. Eur J Immunol. 2005;35: 3516–3524. 10. Hesse M, Piccirillo CA, Belkaid Y, Prufer J, Mentink-Kane M, Leusink M, Cheever AW, Shevach EM, Wynn TA. The pathogenesis of schistosomiasis is controlled by cooperating IL-10- producing innate effector and regulatory T cells. J Immunol. 2004;172:3157–3166. 11. McKee, AS., Pearce, EJ. CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol. 2004;173:1224–1231. 12. Singh, KP., Gerard, HC., Hudson, AP., Reddy, TR, Boros, DL. Retroviral Foxp3 gene transfer ameliorates liver granuloma pathology in Schistosoma mansoni infected mice. Immunology. 2005;114:410–417. 13. JI, J., Masterson, J., Sun, J., Soong, L. CD4+CD25+ regulatory T cellsrestrain pathogenic responses during Leishmania amazonensis infection. J Immunol. 2005;174:7147–7153. 14. Izcue A, Coombes JL, Powrie F. Regulatory T cells suppress systemic and mucosas immune activation to control intestinal inflammation. Immunological Reviews. 2006;212: 256-271.
metadata.dc.format.*:	application/pdf
metadata.dc.type:	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion info:eu-repo/article/published info:eu-repo/article/published info:eu-repo/article/published
Description:	Amebiasis is a parasitic infection caused by E. histolytica, its incidence is higher in developing countries. Recently we have studied the role of Treg cells in several parasitic diseases, which can have beneficial or harmful. The goal of this project was to investigate the role of Treg cells in an immunosuppressive phenomenon previously observed on mouse model of intestinal amoebiasis. Thus, the behavior of Treg population cells was studied at different periods post-infection. However, the results suggest that Treg cells are not involved in this phenomenon of immunosuppression. La amibiasis es una infección causada por el parásito E. histolytica, que tiene alta incidencia en países en vía de desarrollo. En los últimos años se ha estudiado el papel de las células Treg en varias enfermedades parasitarias, que pueden llegar a tener efectos benéficos o perjudiciales. El objetivo central de este proyecto fue investigar la participación de las células Treg en un fenómeno de inmunosupresión observada previamente en un modelo murino de amibiasis intestinal. Para ello se estudió el comportamiento poblacional de las células Treg a diferentes periodos post-infección. Sin embargo, los resultados obtenidos perecen sugerir que las células Treg no participan en este fenómeno de inmunosupresión.
metadata.dc.source:	NOVA Biomedical Sciences Journal; Vol. 8, Núm. 13 (2010); 20-26 Nova; Vol. 8, Núm. 13 (2010); 20-26 NOVA Ciências Biomédicas Publicação; Vol. 8, Núm. 13 (2010); 20-26 2462-9448 1794-2470
URI:	https://repository.unad.edu.co/handle/10596/29965
Other Identifiers:	http://hemeroteca.unad.edu.co/index.php/nova/article/view/435 10.22490/24629448.435
Appears in Collections:	Revista Nova

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