Please use this identifier to cite or link to this item: https://repository.unad.edu.co/handle/10596/30052
Title: Behaviour and Prognostic Value of Serum Cardiac Troponin I in Patients with End-Stage Renal Disease Undergoing Long-Term Haemodialysis. A Five-Year Outcome Analysis
Comportamiento y valor pronóstico de la troponina I cardiaca en suero en pacientes con enfermedad renal final sometidos a hemodiálisis de largo plazo. Analisis de resultados quinquenales
metadata.dc.creator: Almonacid Urrego, Carmen Cecilia
Cantillo Turbay, Jorge de Jesús
Tuñón, María Jesús
Keywords: Ciencias Médicas y de la Salud,Medicina Clínica,Otros Temas de Medicina Clínica;biomarcadores cardíacos; insuficiencia renal crónica; lesión miocárdica; troponina I cardiaca; mortalidad de hemodiálisis; valor pronóstico de la troponina I cardiaca;cardiac biomarkers, cardiac troponin I, chronic renal failure, haemodialysis mortality, myocardial injury, prognostic value of cardiac troponin I.
Publisher: Universidad Colegio Mayor de Cundinamarca
metadata.dc.relation: http://hemeroteca.unad.edu.co/index.php/nova/article/view/415/1129
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metadata.dc.type: info:eu-repo/semantics/article
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info:eu-repo/article/published
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Description: Cardiac Troponin I (cTnI) levels are considered an important diagnostic tool in acute coronary events. However, there is controversy over their sensitivity, specificity and prognostic value in haemodialysis (HD) patients. The aim of this study was to explore the behaviour and prognostic value of cardiac troponin I in HD patients. Thirty-four asymptomatic patients undergoing long-term haemodialysis were studied. Samples of blood were collected at the start of the study (pre- and post-dialysis serum), after three years (pre-dialysis serum and plasma, with and without the addition of heterophilic antibody-blocking reagent (HBR) and after five years (pre-dialysis serum).Quantitative cardiac troponin I was measured with an AxSYM cTnI micro-particle enzyme immuno-assay and qualitative cTnI with a Hexagon Troponin immuno-chromatographic one-step test. It did not prove possible to detect any significant association between pre- and post-dialysis cTnI levels.Comparison of results for serum and heparin plasma revealed no statistically significant difference between the level of cTnI and the mean values for plasma and serum with and without the addition of HBR. The cTnI concentrations in the samples without added HBR were lower than in those with HBR, but no statistically significant difference between the mean for cTnI and the mean of samples with and without added HBR was observed. During the study, 35.2% of the population died. A positive association was observed between the cTnI values in the patients still living and those patients who died from ischaemic cardiomyopathy (p = 0.039).The crude risk of death by cardiovascular disease was increased eight-fold (the 95% confidence interval being 1.2 to 51.1) in patients with a cTnI concentration greater than 0.04 ng/mL. Levels of cTnI may reflect occult myocardial ischemia and identify haemodialysis patients who face a greater risk of death.
Los niveles troponina I cardiaca (cTnI) se consideran una importante herramienta de diagnóstico en los eventos coronarios agudos. Sin embargo, hay controversia sobre su sensibilidad, especificidad y valor pronóstico en la hemodiálisis (HD) de los pacientes. El objetivo de este estudio fue explorar el comportamiento y el valor pronóstico de la troponina I cardiaca en pacientes en HD. Se estudiaron treintaicuatro pacientes asintomáticos sometidos a hemodiálisis a largo plazo. Las muestras de sangre fueron tomadas al inicio del estudio (pre-y post-diálisis en suero), después de tres años (pre-diálisis en suero y plasma, con y sin la adición de anticuerpos heterófilos reactivos de bloqueo (HBR) y después de cinco años (suero pre-diálisis). Se midió la troponina I cardiaca cuantitativa con micro-partículas AxSYM cTnI de la enzima inmuno-ensayo de cTnI y la cualitativa con una prueba de un solo paso de inmuno Troponina Hexagon-cromatografía.No fue posible detectar ninguna asociación significativa entre los niveles de cTnI pre-y post-diálisis. La comparación de los resultados de la heparina de suero y plasma no reveló ninguna diferencia estadísticamente significativa entre el nivel de cTnI y los valores promedio para el plasma y suero con y sin la adición de HBR.Las concentraciones cTnI en las muestras sin HBR añadido fueron más bajas que en aquellas con HBR, pero no se observó diferencia estadísticamente significativa entre la media de cTnI y la media de las muestras con y sin adición de HBR. Durante el estudio, el 35,2% de la población murió. Se observó una asociación positiva entre los valores de cTnI en los pacientes que aún viven y en los pacientes que murieron a causa de la miocardiopatía isquémica (p = 0,039). El crudo riesgo de muerte por enfermedad cardiovascular se ha multiplicado por ocho (el intervalo de 95% de confianza estando entre 1,2 y 51,1) en pacientes con una concentración de cTnI superior a 0,04 ng/ml. Los niveles de cTnI pueden reflejar la isquemia miocárdica oculta e identificar los pacientes en hemodiálisis que se enfrentan a un mayor riesgo de muerte.
metadata.dc.source: NOVA Biomedical Sciences Journal; Vol. 7, Núm. 11 (2009); 34-42
Nova; Vol. 7, Núm. 11 (2009); 34-42
NOVA Ciências Biomédicas Publicação; Vol. 7, Núm. 11 (2009); 34-42
2462-9448
1794-2470
URI: https://repository.unad.edu.co/handle/10596/30052
Other Identifiers: http://hemeroteca.unad.edu.co/index.php/nova/article/view/415
10.22490/24629448.415
Appears in Collections:Revista Nova

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