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https://repository.unad.edu.co/handle/10596/61048| Title: | Chemodrug resistance: Cancer’s fight for survival Chemodrug resistance: Cancer’s fight for survival |
| metadata.dc.creator: | Alcántara Colin, Jafet Sandoval Cabrera, Antonio Martinez Quintero, Daniel Alejandro Santillán Benítez , Jonnathan Guadalupe |
| Keywords: | Cancer;Resistance;Chemoresistance;Cytochrome P450;Cancer;Resistance;Chemoresistance;Cytochrome P450 |
| Publisher: | Universidad Nacional Abierta y a Distancia UNAD |
| metadata.dc.relation: | https://hemeroteca.unad.edu.co/index.php/nova/article/view/7535/6518 |
| metadata.dc.format.*: | application/pdf |
| metadata.dc.type: | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion reviewArticle reviewArticle reviewArticle |
| Description: | Introduction. Chemoresistance is a multifactorial phenomenon implicated in all failed therapies and accounts for 90% of all cancer deaths and 30% of relapses. Objective. To understand the genetic mechanisms by which cancer cells acquire resistance to chemo drugs. Methodology. A non-systematic review study was carried out, in which genes and proteins involved in chemoresistance were searched using the terms “Cancer Drug resis-tance [Title/Abstract]”. From the articles obtained, highly involved genes, emerging genes, and proteins related to resistance were recognized. To obtain more specific information about genes, their interactions, and proteins associated with metabolism, the tools “The Human Protein Atlas”, “STRING CONSORTIUM 2022,” and The Small Molecule Pa- thway Database were used for their review. Results. From this review it was found that there are genes highly related to resistance such as: ABCA3, ABCB1, ABCB2, ABCC1, ABCC2, ABCG2, CYP2D6, CYP3A4, GSTA1. Recently recognised genes such as: FOXO3,FOXM1, Skp2, Snail, Twist1, ZEB1 and SLCO1B3. Conclusions. It is necessary to taking account new approaches related to cancer treatments considering chemoresistence and the genes related to the resistence. Introduction. Chemoresistance is a multifactorial phenomenon implicated in all failed therapies and accounts for 90% of all cancer deaths and 30% of relapses. Objective. To understand the genetic mechanisms by which cancer cells acquire resistance to chemo drugs. Methodology. A non-systematic review study was carried out, in which genes and proteins involved in chemoresistance were searched using the terms “Cancer Drug resis- tance [Title/Abstract]”. From the articles obtained, highly involved genes, emerging genes, and proteins related to resistance were recognized. To obtain more specific information about genes, their interactions, and proteins associated with metabolism, the tools “The Human Protein Atlas”, “STRING CONSORTIUM 2022,” and The Small Molecule Pa- thway Database were used for their review. Results. From this review it was found that there are genes highly related to resistance such as: ABCA3, ABCB1, ABCB2, ABCC1, ABCC2, ABCG2, CYP2D6, CYP3A4, GSTA1. Recently recognised genes such as: FOXO3, FOXM1, Skp2, Snail, Twist1, ZEB1 and SLCO1B3. Conclusions. It is necessary to taking account new approaches related to cancer treatments considering chemoresistence and the genes related to the resistence. |
| metadata.dc.source: | NOVA Biomedical Sciences Journal; Vol. 21 No. 41 (2023): International Issue Revista Nova publicación científica en ciencias biomédicas; Vol. 21 Núm. 41 (2023): Número Internacional NOVA Ciências Biomédicas Publicação; v. 21 n. 41 (2023): Número Internacional 2462-9448 1794-2470 |
| Other Identifiers: | https://hemeroteca.unad.edu.co/index.php/nova/article/view/7535 10.22490/24629448.7535 |
| Appears in Collections: | Revista Nova |
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