Morphogenesis of penis and spongy urethraduring human gestation

Valencia , Alba Rocío; García Florez , Manuel

Please use this identifier to cite or link to this item: https://repository.unad.edu.co/handle/10596/61051

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DC Field	Value	Language
dc.creator	Valencia , Alba Rocío	en
dc.creator	García Florez , Manuel	en
dc.date	2023-12-16	-
dc.identifier	https://hemeroteca.unad.edu.co/index.php/nova/article/view/7540	-
dc.identifier	10.22490/24629448.7540	-
dc.description	Background. Every year, approximately 500,000 children in the world are born withcongenital abnormalities of the urinary system and kidneys. Therefore, pediatricians andurologists must understand the normal processes that lead to male sexual differentiation.Objective. The aim of this study was to describe in detail the process that occurs duringmasculinization of the fetus, which leads to the formation of male structures under normalconditions. Methods. Fifty-four fetuses with gestation periods between four and 18 weekswere collected, which were considered normal, did not have any signs of external anatomicabnormalities or any alteration in their development, and were a product of spontaneousabortions and tubal pregnancies. The urogenital sinus region was collected and preparedfor scanning electron microscopy and high-resolution optical microscopy to observe thecellular characteristics of the urogenital fold during external development in male embryos. Results. This work shows the formation of the glans and spongy urethra in a detailed man-ner from the eighth week of embryonic development, carefully describing the role of the labioscrotal folds and the fusion of the walls of the urogenital fold during the subsequent stages of development to form the proximal part of the urinary tract. Conclusion. The for-mation of the penile urethra from the urethral fold and its posterior fusion have a probable role of ectodermal cells, in addition to the endodermal origin established previously.	en
dc.description	Background. Every year, approximately 500,000 children in the world are born with congenital abnormalities of the urinary system and kidneys. Therefore, pediatricians and urologists must understand the normal processes that lead to male sexual differentiation. Objective. The aim of this study was to describe in detail the process that occurs during masculinization of the fetus, which leads to the formation of male structures under normal conditions. Methods. Fifty-four fetuses with gestation periods between four and 18 weeks were collected, which were considered normal, did not have any signs of external anatomic abnormalities or any alteration in their development, and were a product of spontaneous abortions and tubal pregnancies. The urogenital sinus region was collected and prepared for scanning electron microscopy and high-resolution optical microscopy to observe the cellular characteristics of the urogenital fold during external development in male embryos. Results. This work shows the formation of the glans and spongy urethra in a detailed man- ner from the eighth week of embryonic development, carefully describing the role of the labioscrotal folds and the fusion of the walls of the urogenital fold during the subsequent stages of development to form the proximal part of the urinary tract. Conclusion. The for- mation of the penile urethra from the urethral fold and its posterior fusion have a probable role of ectodermal cells, in addition to the endodermal origin established previously.	es
dc.format	application/pdf	-
dc.language	spa	-
dc.publisher	Universidad Nacional Abierta y a Distancia UNAD	es
dc.relation	https://hemeroteca.unad.edu.co/index.php/nova/article/view/7540/6514	-
dc.rights	Derechos de autor 2023 Nova	es
dc.rights	https://creativecommons.org/licenses/by-nc-nd/4.0	es
dc.source	NOVA Biomedical Sciences Journal; Vol. 21 No. 41 (2023): International Issue	en
dc.source	Revista Nova publicación científica en ciencias biomédicas; Vol. 21 Núm. 41 (2023): Número Internacional	es
dc.source	NOVA Ciências Biomédicas Publicação; v. 21 n. 41 (2023): Número Internacional	pt-BR
dc.source	2462-9448	-
dc.source	1794-2470	-
dc.subject	Urogenital System	en
dc.subject	SRY gene	en
dc.subject	Sex differentiation	en
dc.subject	Sex determination	en
dc.subject	Gestational age	en
dc.subject	Urogenital system	es
dc.subject	SRY gene	es
dc.subject	Sex differentiation	es
dc.subject	Sex determination	es
dc.subject	Gestational age	es
dc.title	Morphogenesis of penis and spongy urethraduring human gestation	en
dc.title	Morphogenesis of penis and spongy urethra during human gestation	es
dc.type	info:eu-repo/semantics/article	-
dc.type	info:eu-repo/semantics/publishedVersion	-
dc.type	article	en
dc.type	article	es
dc.type	article	pt-BR
Appears in Collections:	Revista Nova

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