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https://repository.unad.edu.co/handle/10596/46818| Title: | Characterization of molecular alterations of hemoglobin in Afro-Colombians Caracterización de alteraciones en la molécula de hemoglobina en afrodescendientes colombianos |
| metadata.dc.creator: | Castillo, Martha Oliveros, Ana Lucia |
| Keywords: | Afro-Colombian;Hemoglobinopathies;iron deficiencies;anemias.;afrodescendiente;hemoglobinopatías;ferropenias;anemias. |
| Publisher: | Universidad Colegio Mayor de Cundinamarca |
| metadata.dc.relation: | https://hemeroteca.unad.edu.co/index.php/nova/article/view/1039/1036 |
| metadata.dc.format.*: | application/pdf |
| metadata.dc.type: | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion info:eu-repo/article/published info:eu-repo/article/published info:eu-repo/article/published |
| Description: | Objective: Characterize molecular alterations of hemoglobin in Afro-Colombian subjects, ranging in age from 18 to 50 years. Analyses were conducted via complete blood count, peripheral blood smear, C-Reactive Protein, serum Ferritin, Soluble Transferrin Receptor (sTfR) and electrophoresis. Materials and Methods: A total of 56 subjects were analyzed, 10 men and 46 women. Results: Subjects (from the Aguablanca District in the City of Cali) showed alterations in the hemoglobin chain associated with Hemoglobin S, Hemoglobin C and possible thalassemias due to Fetal Hemoglobin and augmented Hemoglobin A2. Additionally, a small incidence of subclinical deficiencies of iron at different stages was also detected. Caracterizar alteraciones de la molécula de hemoglobina en afrodescendientes entre 18 a 50 años, a través de hemograma, estudio de sangre periférico, proteína C Reactiva, ferritina sérica, receptor soluble de transferrina sRTf y electroforesis de Hemoglobina. Materiales y métodos: Esta investigación contó con un total de 56 muestras: 10 hombres y 46 mujeres. Resultados: La población en estudio perteneciente al Distrito de Aguablanca en la Ciudad de Cali presentó alteraciones en la cadena de hemoglobina asociada a Hemoglobina S, Hemoglobina C y posible talasemias por presencia de Hemoglobina Fetal y Hemoglobina A2 aumentadas. También se presentaron deficiencias de hierro, aunque en baja proporción, en diferentes estadios con respecto a la población general. |
| metadata.dc.source: | NOVA Biomedical Sciences Journal; Vol. 12 No. 22 (2014); 151-155 Nova; Vol. 12 Núm. 22 (2014); 151-155 NOVA Ciências Biomédicas Publicação; v. 12 n. 22 (2014); 151-155 2462-9448 1794-2470 |
| URI: | https://repository.unad.edu.co/handle/10596/46818 |
| Other Identifiers: | https://hemeroteca.unad.edu.co/index.php/nova/article/view/1039 10.22490/24629448.1039 |
| Appears in Collections: | Revista Nova |
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