Selecting a spray system for the formation of Eudragit ® S100 microparticles in a fluid bed

Camacho Kurmen, Judith Elena; Gómez, Martha Isabel; Villamizar, Laura Fernanda

dc.creator	Camacho Kurmen, Judith Elena
dc.creator	Gómez, Martha Isabel
dc.creator	Villamizar, Laura Fernanda
dc.date	2010-06-15
dc.date.accessioned	2019-11-08T21:24:11Z
dc.date.available	2019-11-08T21:24:11Z
dc.identifier	http://hemeroteca.unad.edu.co/index.php/nova/article/view/442
dc.identifier	10.22490/24629448.442
dc.identifier.uri	https://repository.unad.edu.co/handle/10596/29801
dc.description	The development of microparticles in fluid bed is of high interest in the pharmaceutical, food and agriculture, as this type of formulation to control the release of active ingredients and their stability and functionality by the formation of small solid particles. The fluid bed equipment is commonly used in industry to carry out the process and this can have two sets of spray drying: top spray and bottom spray. In this study we evaluated the two sets of spray drying towards the formation of microparticles of Eudragit®S100. Experiments were conducted toad just the itical process factors and theirevelsusingamultilevel factorial designand working in a Glattfluid bedbrandGmbHD-01277. Factors evaluated were the inlet temperature, the pressure inside he chamber and the flow rate.The coating material consisted of a methacrylicacid polymer known asEudragit® S100andcore325 meshpowderwasused. The system selected for the microencapsulation was top spray. The spray dryingconditions were set flow rate of4.12 mL/min (flow 8 rpm), inlet temperature of 80ºC and pressure inside the chamber 1 and 3 bars.The microparticles showed homogeneous shapes and sizes, less than 100 microns. The conditions set for the top spray system can be applied to the development of microencapsulation processes of different active ingredients using as polymer Eudragit® S100.	en-US
dc.description	La elaboración de micropartículas en lecho fluido es de gran interés en la industria farmacéutica, alimentaria y agrícola, ya que este tipo de formulación permite controlar la liberación de ingredientes activos y su estabilidad y funcionalidad mediante la formación de pequeñas partículas sólidas. El lecho fluido es el equipo comúnmente usado en la industria para realizar el proceso y éste puede tener dos sistemas de atomización: superior (Top spray) e inferior (Bottom spray). En este trabajo se evaluaron los dos sistemas de atomización con miras a la formación de micropartículas de Eudragit® S100.Se realizaron experimentos para ajustar los factores críticos del proceso y los niveles de éstos utilizando un diseño factorial multinivel y trabajando en un lecho fluido marca Glatt GmbH D – 01277. Los factores evaluados fueron la temperatura de entrada, la presión interna de la cámara y la velocidad de flujo. El material de recubrimiento consistió en un polímero del ácido metacrílico denominado Eudragit® S100 y como núcleo se empleó talco malla 325. El sistema seleccionado para la microencapsulación fue el de atomización superior (Top spray). Las condiciones de atomización establecidas fueron velocidad de flujo de 4,12 mL/min (flujo 8 rpm), temperatura de entrada de80ºC y presión interna de la cámara de 1 y 3 bares. Las micropartículas presentaron formas y tamaños homogéneos, menores de 100 μm.Las condiciones fijadas para el sistema de atomizaciónsuperior se pueden aplicar al desarrollo de procesos de microencapsulación de diferentes principios activos utilizando como polímero Eudragit® S100.	es-ES
dc.format	application/pdf
dc.language	spa
dc.publisher	Universidad Colegio Mayor de Cundinamarca	es-ES
dc.relation	http://hemeroteca.unad.edu.co/index.php/nova/article/view/442/1115
dc.relation	/ref/Li X., Anton N, Arpagaus C, Belleteix F, Vandamme Th. 2010. Nanoparticles by Spray drying using innovate new technology: The Büchi Nano Spray Dryer B-90. Journal of Controlled Release 147: 304-310 2. Beck R. C. R, Pohlmann A. R, Guterres S. 2004. Nanoparticle-coated microparticles: preparation and characterization. J. Microencapsula-tion. 21: 499–512 3. Yu C, Wang W, Yao H, Liu H. 2007. Preparation of Phospholipid Microcapsule by Spray Drying. Drying Technology 25: 695–702 4. Liu Ch, Liu S-D. 2009. Low-Temperature Spray Drying for the Microencapsulation of the Fungus Beauveria bassiana. Drying Technology 27:747–753 5. Bürki K, Jeon I, Arpagaus C, Betz G. 2011. New insights into respirable protein powder preparation using a nano spray dryer. International Journal of Pharmaceutics 408: 248–256 6. Winder R S, Wheeler J J, Conder N, Otvos I S, Nevill R, Duan L. 2003. Microencapsulation: A Strategy for Formulation of Inoculum Biocontrol. Science and Technology 13:155-169 7. Fini A, Cavallari C, Ospitali F. 2008. Raman and thermal analysis of indomethacin/PVP solid dispersion enteric microparticles. European Journal of Pharmaceutics and Biopharmaceutics 70: 409–420 8. Ronsse F, Pieters J, Dewettinck K. 2008. Modelling side-effect spray drying in top-spray fluidized bed coating processes. Journal of Food Engineering 86: 529–541 9. Turchiuli C, Gianfrancesco A, Palzer S, Dumoulin E. 2011. Evolution of particle properties during spray drying in relation with stickiness and agglomeration control.Powder Technology 208: 433–440 10. Tajber L, Corrigan O, Healy A. 2009. Spray drying of budesonide, formoterol fumarate and their Composites—II. Statistical factorial design and in vitro deposition properties. International Journal of Pharmaceutics 367: 86–96 11. Srivastava S, Mishra G. 2010. Fluid Bed Technology: Overview and Parameters for Process Selection. International Journal of Pharmaceutical Sciences and Drug Research 2: 236-246 12. Ronsse F, Pieters J. G, Dewettinck K. 2009. Modelling heat and mass transfer in batch, top-spray fluidised bed coating processes. Powder Technology 190: 170–175 13. Mafadi S, Hayert M, Poncelet D. 2003. Fluidization Control in the Wurster Coating Process. Chem. Ind. 57: 641-644) 14. Fitzpatrick S, Ding Y, Seiler Ch, Lovegrove C, Booth S, Forster R, Parker R, Jonathan S. 2003.Positron Emission Particle Tracking Studies of a Wurster Process for Coating Applications.Pharmaceutical Technology 70-78. 15. Glatt. com http://www.glatt.com/e/01_tecnologien/01_04_09.htm (consulta septiembre del 2010) 16. Cheow W, Li S, Hadinoto K. 2010.Spray drying formulation of hollow spherical aggregates of silicananoparticles by experimental design chemical engineering research and design 88: 673–685 17. Kho K, Hadinoto K. 2010a. Effects of excipient formulation on the morphology and aqueous re dispersibility of dry-powder silica nanoaggregates Colloids and Surfaces A. Physicochem. Eng. Aspects 359: 71–81 18. Kho K, Hadinoto K. 2010b. Aqueous re-dispersibility characterization of spray-dried hollow spherical silica nano-aggregates. Powder Technology 198: 354–363 19. Villamizar L, Martínez F.2008. Determination of the basic conditions for microencapsulation of an enthomopathogenic Baculovirus by means of coacervation using Eudragit S100®. VITAE 15:123- 131 20. Lopedota A, Trapani A, Cutrignelli A, Chiarantini L, Pantucci E, Curci R, Manuali E, Trapani G. 2009. The use of Eudragit® RS100/cyclodextrin nanoparticles for transmucosal administration of glutathione. European Journal of Pharmaceutics and Biopharmaceutics 72: 509-520 21. Villamizar L, Barrera G, Cotes A, Martínez F.2010. Eudragit S100 microparticles containing Spodoptera frugiperda nucleopolyehedrovirus: Physicochemical, characterization,photostability and invitro virus release. J. Microencapsulation 27:314-324 22. Charpentier A, Gadielle P, Benoit P. 1999. Rhizobacteria microencapsulation : properties of microparticles obtained by spray-drying. J. Microencapsulation 16: 215-229 23. Tamez P, McGuire M, Behle R, Shasha B, Pingel R. 2002. Storage Stability of Anagrapha falcifera nucleopolyehedrovirus in spray dried formulations. Journal of Invertebrate Pathology 79: 7–16 24. Behle R, Tamez-Guerra P, Mcguire M. 2006. Evaluating conditions for producing spray-dried formulations of Anagrapha falcifera nucleopolyhedroviruses (AfMNPV). Biocontrol Science and Technology 16:941-952 25. Young S. 2005. Persistence of viruses in environment.http: www.Agctr.isu.edu/s265/young.html (consulta septiembre 2010). 26. Jin X, Custis D. 2011. Microencapsulating aerial conidia of Trichoderma harzianum through spray drying at elevated temperatures. Biological Control 56: 202–208 27. Johansen P, Merkle H, Gander B. 2000. Technological considerations related to the up-scaling of prote in microencapsulation by spray-drying. European Journal of Pharmaceutics and Biopharmaceutics 50:413-417 28. Horaczek A, Viernstein H. 2004. Comparison of three commonly used drying technologies with respect to activity and longevity of aerial conidia of Beauveria brongniartii and Metarhizium anisopliae. Biological Control 31: 65–71 29. Hede P, Bach P, Jensen A. 2008. Top-spray fluid bed coating: Scale-up in terms of relative droplet size and drying force. Powder Technology
dc.rights	Copyright (c) 2010 NOVA Publicación en Ciencias Biomédicas	es-ES
dc.rights	http://creativecommons.org/licenses/by/4.0	es-ES
dc.source	NOVA Biomedical Sciences Journal; Vol. 8, Núm. 13 (2010); 87-100	en-US
dc.source	Nova; Vol. 8, Núm. 13 (2010); 87-100	es-ES
dc.source	NOVA Ciências Biomédicas Publicação; Vol. 8, Núm. 13 (2010); 87-100	pt-BR
dc.source	2462-9448
dc.source	1794-2470
dc.subject	Ciencias Naturales,Ciencias Biológicas,Otras Biologías	es-ES
dc.subject	Microencapsulación; micropartículas; Eudragit®; atomización superior; atomización inferior; factores críticos	es-ES
dc.subject	Microencapsulation; microparticles; Eudragit®; Top spray; Bottom spray; critical factors	en-US
dc.title	Selecting a spray system for the formation of Eudragit ® S100 microparticles in a fluid bed	en-US
dc.title	Selección de un sistema de atomización para la formación de micropartículas de Eudragit® S100 en lecho fluido	es-ES
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	info:eu-repo/article/published	en-US
dc.type	info:eu-repo/article/published	es-ES
dc.type	info:eu-repo/article/published	pt-BR