Chemodrug resistance: Cancer’s fight for survival

Alcántara Colin, Jafet; Sandoval Cabrera, Antonio; Martinez Quintero, Daniel Alejandro; Santillán Benítez , Jonnathan Guadalupe

dc.creator	Alcántara Colin, Jafet	en
dc.creator	Sandoval Cabrera, Antonio	en
dc.creator	Martinez Quintero, Daniel Alejandro	en
dc.creator	Santillán Benítez , Jonnathan Guadalupe	en
dc.date	2023-12-16
dc.identifier	https://hemeroteca.unad.edu.co/index.php/nova/article/view/7535
dc.identifier	10.22490/24629448.7535
dc.description	Introduction. Chemoresistance is a multifactorial phenomenon implicated in all failed therapies and accounts for 90% of all cancer deaths and 30% of relapses. Objective. To understand the genetic mechanisms by which cancer cells acquire resistance to chemo drugs. Methodology. A non-systematic review study was carried out, in which genes and proteins involved in chemoresistance were searched using the terms “Cancer Drug resis-tance [Title/Abstract]”. From the articles obtained, highly involved genes, emerging genes, and proteins related to resistance were recognized. To obtain more specific information about genes, their interactions, and proteins associated with metabolism, the tools “The Human Protein Atlas”, “STRING CONSORTIUM 2022,” and The Small Molecule Pa- thway Database were used for their review. Results. From this review it was found that there are genes highly related to resistance such as: ABCA3, ABCB1, ABCB2, ABCC1, ABCC2, ABCG2, CYP2D6, CYP3A4, GSTA1. Recently recognised genes such as: FOXO3,FOXM1, Skp2, Snail, Twist1, ZEB1 and SLCO1B3. Conclusions. It is necessary to taking account new approaches related to cancer treatments considering chemoresistence and the genes related to the resistence.	en
dc.description	Introduction. Chemoresistance is a multifactorial phenomenon implicated in all failed therapies and accounts for 90% of all cancer deaths and 30% of relapses. Objective. To understand the genetic mechanisms by which cancer cells acquire resistance to chemo drugs. Methodology. A non-systematic review study was carried out, in which genes and proteins involved in chemoresistance were searched using the terms “Cancer Drug resis- tance [Title/Abstract]”. From the articles obtained, highly involved genes, emerging genes, and proteins related to resistance were recognized. To obtain more specific information about genes, their interactions, and proteins associated with metabolism, the tools “The Human Protein Atlas”, “STRING CONSORTIUM 2022,” and The Small Molecule Pa- thway Database were used for their review. Results. From this review it was found that there are genes highly related to resistance such as: ABCA3, ABCB1, ABCB2, ABCC1, ABCC2, ABCG2, CYP2D6, CYP3A4, GSTA1. Recently recognised genes such as: FOXO3, FOXM1, Skp2, Snail, Twist1, ZEB1 and SLCO1B3. Conclusions. It is necessary to taking account new approaches related to cancer treatments considering chemoresistence and the genes related to the resistence.	es
dc.format	application/pdf
dc.language	spa
dc.publisher	Universidad Nacional Abierta y a Distancia UNAD	es
dc.relation	https://hemeroteca.unad.edu.co/index.php/nova/article/view/7535/6518
dc.rights	Derechos de autor 2023 Nova	es
dc.rights	https://creativecommons.org/licenses/by-nc-nd/4.0	es
dc.source	NOVA Biomedical Sciences Journal; Vol. 21 No. 41 (2023): International Issue	en
dc.source	Revista Nova publicación científica en ciencias biomédicas; Vol. 21 Núm. 41 (2023): Número Internacional	es
dc.source	NOVA Ciências Biomédicas Publicação; v. 21 n. 41 (2023): Número Internacional	pt-BR
dc.source	2462-9448
dc.source	1794-2470
dc.subject	Cancer	en
dc.subject	Resistance	en
dc.subject	Chemoresistance	en
dc.subject	Cytochrome P450	en
dc.subject	Cancer	es
dc.subject	Resistance	es
dc.subject	Chemoresistance	es
dc.subject	Cytochrome P450	es
dc.title	Chemodrug resistance: Cancer’s fight for survival	en
dc.title	Chemodrug resistance: Cancer’s fight for survival	es
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	reviewArticle	en
dc.type	reviewArticle	es
dc.type	reviewArticle	pt-BR