Efectos tóxicos del paracetamol en la salud humana y el ambiente

Acevedo-Barrios, Rosa Leonor; Severiche-Sierra, Carlos Alberto; Jaimes Morales, Jose Del Carmen

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Acevedo-Barrios, Rosa Leonor

Severiche-Sierra, Carlos Alberto

Jaimes Morales, Jose Del Carmen

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Universidad Nacional Abierta y a Distancia, UNAD

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Abstract

En este artículo se detallan los efectos tóxicos del paracetamol en la salud humana y el ambiente, detallando las generalidades del paracetamol APAP. El metabolismo del APAP y factores potenciales que influyen en su toxicidad, pasando por estudios de toxicidad y por último el destino ambiental. El paracetamol es un analgésico de uso común, presenta alta hidrosolubilidad, eliminándose hasta un 90% por gluconación o sulfación; pero su metabólito N-acetil-para-benzoilquinoneimina en ocasiones se expulsa por medio de las heces y orina, volviéndose un compuesto toxico persistente. Se observan efectos crónicos principalmente en organismos acuáticos, a través de la exposición a diferentes concentraciones de APAP durante un prolongado período de tiempo.

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http://hemeroteca.unad.edu.co/index.php/riaa/article/view/1845/2226
http://hemeroteca.unad.edu.co/index.php/riaa/article/view/1845/2064
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