Modulation of the Lipids Levels and Lipoproteins for the Polymorphism of the Apolipoprotein E

Torres PhD, Ana Lucia; Guerra de Muñoz MSC, Martha; Segrera, Adriana; Wagner, Jenny; Álvarado MSC, Martha

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Torres PhD, Ana Lucia

Guerra de Muñoz MSC, Martha

Segrera, Adriana

Wagner, Jenny

Álvarado MSC, Martha

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Universidad Colegio Mayor de Cundinamarca

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Abstract

El objetivo del presente trabajo fue estudiar el efecto del polimorfismo genético de la Apolipoproteína E (Apo E) sobre los niveles plasmáticos de lípidos y lipoproteínas en una cohorte de 200 individuos adultos sanos (20-65 años) residentes en Bogotá D.C. La frecuencia de los alelos de la Apo E fue 0.05 para el alelo e2; 0.87 para el e3 y 0.08 para el alelo e4. Los individuos se clasificaron de acuerdo al genotipo de la ApoE en: E3/2, E3/3, E4/3, E4/4 y E4/2, el genotipo de mayor frecuencia fue el E3/3 (77.1%). Al comparar la colesterolemia entre los sujetos E3/2, E3/3 y E4/3 se observaron niveles incrementados significativamente (p<0.05) en el grupo E4/3 (172.1±16.9) comparados con los del grupo E3/2 (148.7±32.1). Los niveles de triglicéridos presentaron una tendencia hacia niveles más altos en los individuos con genotipo Apo E4/3 al cómpralos con E3/3 y E3/2. En la población estudiada, el polimorfismo de la ApoE es un importante determinante genético de los niveles plasmáticos de lípidos y lipoproteínas, es así como la presencia del alelo e4 de la Apo E puede influir en el incremento de los niveles de colesterol total, colesterol-LDL y triglicéridos siendo un factor de riesgo de enfermedad cardiovascular.

The objective of the present work was to study the genetic polymorphism of apo E and his effect on plasma lipids and lipoproteins levels in one cohort of 200 healthy adult individuals (20-65 years) resident in Bogotá D.C. The frequency of apo E gene alleles was 0.05 for e2; 0.87 for e3 and 0.08 for e4. The individuals were classified according to the ApoE genotype in: e3/2, e3/3, e4/3, e4/4 and e4/2. The genotype of greater frequency (77.1%) was e3/3. When comparing the cholesterol levels between the subjects E3/2, E3/3 and E4/3, significantly (p<0.05) increased levels were observed in the E4/3 group (172.1±16.9) compared with the E3/2 (148.7±32.1) group. The triglyceride levels showed a tendency towards higher levels in the group of individuals with apo E4/3 genotype compared to E3/3 and E3/2 groups. In these population studied, the ApoE polymorphism is an important genetic determinant of lipid and lipoprotein levels, the presence of e4 allele of ApoE gene determine increased levels of total cholesterol, cholesterol-LDL and triglycerides being these important risk factors for cardiovascular disease developpement.

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http://hemeroteca.unad.edu.co/index.php/nova/article/view/16/1223
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Modulación de los Niveles de Lípidos y Lipoproteinas por el Polimorfismo de la Apolipoproteina E en Individuos Sanos de Bogota D.C.