Mostrar registro simples

Modulación de los Niveles de Lípidos y Lipoproteinas por el Polimorfismo de la Apolipoproteina E en Individuos Sanos de Bogota D.C.

Modulation of the Lipids Levels and Lipoproteins for the Polymorphism of the Apolipoprotein E

dc.creatorTorres PhD, Ana Lucia
dc.creatorGuerra de Muñoz MSC, Martha
dc.creatorSegrera, Adriana
dc.creatorWagner, Jenny
dc.creatorÁlvarado MSC, Martha
dc.date2005-06-15
dc.date.accessioned2019-11-08T21:24:41Z
dc.date.available2019-11-08T21:24:41Z
dc.identifierhttp://hemeroteca.unad.edu.co/index.php/nova/article/view/16
dc.identifier10.22490/24629448.16
dc.identifier.urihttps://repository.unad.edu.co/handle/10596/29920
dc.descriptionThe objective of the present work was to study the genetic polymorphism of apo E and his effect on plasma lipids and lipoproteins levels in one cohort of 200 healthy adult individuals (20-65 years) resident in Bogotá D.C. The frequency of apo E gene alleles was 0.05 for e2; 0.87 for e3 and 0.08 for e4. The individuals were classified according to the ApoE genotype in: e3/2, e3/3, e4/3, e4/4 and e4/2. The genotype of greater frequency (77.1%) was e3/3. When comparing the cholesterol levels between the subjects E3/2, E3/3 and E4/3, significantly (p<0.05) increased levels were observed in the E4/3 group (172.1±16.9) compared with the E3/2 (148.7±32.1) group. The triglyceride levels showed a tendency towards higher levels in the group of individuals with apo E4/3 genotype compared to E3/3 and E3/2 groups. In these population studied, the ApoE polymorphism is an important genetic determinant of lipid and lipoprotein levels, the presence of e4 allele of ApoE gene determine increased levels of total cholesterol, cholesterol-LDL and triglycerides being these important risk factors for cardiovascular disease developpement.en-US
dc.descriptionEl objetivo del presente trabajo fue estudiar el efecto del polimorfismo genético de la Apolipoproteína E (Apo E) sobre los niveles plasmáticos de lípidos y lipoproteínas en una cohorte de 200 individuos adultos sanos (20-65 años) residentes en Bogotá D.C. La frecuencia de los alelos de la Apo E fue 0.05 para el alelo e2; 0.87 para el e3 y 0.08 para el alelo e4. Los individuos se clasificaron de acuerdo al genotipo de la ApoE en: E3/2, E3/3, E4/3, E4/4 y E4/2, el genotipo de mayor frecuencia fue el E3/3 (77.1%). Al comparar la colesterolemia entre los sujetos E3/2, E3/3 y E4/3 se observaron niveles incrementados significativamente (p<0.05) en el grupo E4/3 (172.1±16.9) comparados con los del grupo E3/2 (148.7±32.1). Los niveles de triglicéridos presentaron una tendencia hacia niveles más altos en los individuos con genotipo Apo E4/3 al cómpralos con E3/3 y E3/2. En la población estudiada, el polimorfismo de la ApoE es un importante determinante genético de los niveles plasmáticos de lípidos y lipoproteínas, es así como la presencia del alelo e4 de la Apo E puede influir en el incremento de los niveles de colesterol total, colesterol-LDL y triglicéridos siendo un factor de riesgo de enfermedad cardiovascular.es-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherUniversidad Colegio Mayor de Cundinamarcaes-ES
dc.relationhttp://hemeroteca.unad.edu.co/index.php/nova/article/view/16/1223
dc.relation/*ref*/Assman G. Lipid metabolism and coronary heart disease. Primary prevention, diagnosis and therapy guidelines for general practice. Munich: MMV Medizin Verlag, 1993.
dc.relation/*ref*/Ministerio de Salud, Dirección General de Salud Pública, Grupo de Vigilancia en Salud Pública. Mortalidad por grupo etario según causas, Colombia 1999. Fuente: DANE, archivo de defunciones; 2001.
dc.relation/*ref*/Mahley Robert W. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988;240:622-630.
dc.relation/*ref*/Lin-Lee YC, Kao FT, Cheung P, Chan L. Apolipoprotein E gene mapping and expression: Localization of the structural gene to human chromosome 19 and expression of apo E mRNA in lipoprotein- and non-lipoprotein-producing tissues. Biochemistry. 1985;24:3751-3756.
dc.relation/*ref*/Das HK, McPherson J, Bruns GA, Karathanasis SK, Breslow JL. Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene. J. Biol. Chem. 1985;260:6240-6247.
dc.relation/*ref*/Utermann G, Pruin N, Steinmetz A. Polymorphism of apolipoprotein E. III. Effect of a single polymorphic gene locus on plasma lipid levels in man. Clin. Genet. 1979;15:63-72.
dc.relation/*ref*/Zannis VI, Breslow JL, Uthermann G, Mahley RW, Weisgraber KH, Havel RJ, Goldstein JL, Brown MS, Schonfeld G, Hazzard WR, Blum C. Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. J. Lipid Res. 1982;23:911-914.
dc.relation/*ref*/Kamboh MI, Aston CE, Ferrell RE, Hamman RF. Impact of apolipoprotein E polymorphism in determining interindividual variation in total cholesterol and low density lipoprotein cholesterol in Hispanics and non-Hispanic whites. Atherosclerosis. 1993;98:201-211.
dc.relation/*ref*/Boerwinkle E, Utermann G. Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apolipoprotein B, and cholesterol metabolism. Am. J. Hum. Genet. 1988;42:104-112.
dc.relation/*ref*/Utermann G. Genetic polymorphism of apolipoprotein E. Impact on plasma lipoprotein metabolism. In: Crepaldi G, Tiengo A, Baggio G, (eds). Diabetes, obesity and hyperlipidemias-III. Amsterdam: Elsevier Science Publishers, pp. 1-28, 1985.
dc.relation/*ref*/Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988;16: 1215.
dc.relation/*ref*/Hixson JM, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hha I. J. Lipid Res. 1990;31:545-548.
dc.relation/*ref*/Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis.1988;8:1- 21.
dc.relation/*ref*/Hallman DM, Boerwinkle E, Saha N, Sandholzer C, Menzel HJ, Csázár A, Utermann G. The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations. Am. J. Hum. Genet. 1991;49: 338-349.
dc.relation/*ref*/Ehnholm C, Lukka M, Kuusi T, Nikkilä E, Utermann G. Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations. J. Lipid Res. 1986;27: 227-235.
dc.relation/*ref*/Sepehrnia B, Kamboh MI, Adams-Campbell LL, Bunker CH, Nwankwo M, Majumder PP, Ferrell RE. Genetic studies of human apolipoproteins. X. The effect of the apolipoprotein E polymorphism on quantitative levels of lipoproteins in Nigerian blacks. Am. J. Hum. Genet. 1989;45: 586-591.
dc.relation/*ref*/Wardell MR, Suckling PA, Janus ED. Genetic variation in human apolipoprotein E. J. Lipid Res. 1982;23:1174-1182.
dc.relation/*ref*/Dallongeville J, Lussier-Cacan S, Davignon J. Modulation of plasma triglyceride levels by apo E phenotype: A metaanalysis. J. Lipid Res. 1992;33:447-454.
dc.relation/*ref*/Boerwinkle E, Vivvikis S, Welsh D, Steinmetz J, Hanash SM, Sing CF. The use of measured genotype information in the analysis of quantitative phenotypes in man.II. The role of the apolipoprotein E polymorphism in determining levels, variability, and covariability of cholesterol, betalipoprotein, and triglycerides in a sample of unrelated individuals. Am. J. Med. Genet. 1987; 27:567-582.
dc.rightsCopyright (c) 2005 NOVA Publicación en Ciencias Biomédicases-ES
dc.rightshttp://creativecommons.org/licenses/by/4.0es-ES
dc.sourceNOVA Biomedical Sciences Journal; Vol. 3, Núm. 3 (2005); 31-35en-US
dc.sourceNova; Vol. 3, Núm. 3 (2005); 31-35es-ES
dc.sourceNOVA Ciências Biomédicas Publicação; Vol. 3, Núm. 3 (2005); 31-35pt-BR
dc.source2462-9448
dc.source1794-2470
dc.subjectPolymorphisms; lipids; apolipoprotein E; cardiovascular disease.en-US
dc.subjectPolimorfismo; lípidos; apolipoproteína E; enfermedad cardiovascular.es-ES
dc.titleModulation of the Lipids Levels and Lipoproteins for the Polymorphism of the Apolipoprotein Een-US
dc.titleModulación de los Niveles de Lípidos y Lipoproteinas por el Polimorfismo de la Apolipoproteina E en Individuos Sanos de Bogota D.C.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typearticleen-US
dc.typearticlees-ES
dc.typearticlept-BR


Arquivos deste item

ArquivosTamanhoFormatoVisualização

Não existem arquivos associados a este item.

Este item aparece na(s) seguinte(s) coleção(s)

Mostrar registro simples