Determinación perinatal de leptina en madres y neonatos condiagnóstico de retardo de crecimiento intrauterino (RCIU)

Muñoz Molina M.Sc., Liliana; Sabogal MD, Juan Carlos; Arteaga M.Sc., Clara; Hernández M.Sc., Rubistein; Mockus MD, Ismena; Tovar Ph.D, Jairo

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Muñoz Molina M.Sc., Liliana

Sabogal MD, Juan Carlos

Arteaga M.Sc., Clara

Hernández M.Sc., Rubistein

Mockus MD, Ismena

Tovar Ph.D, Jairo

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Universidad Colegio Mayor de Cundinamarca

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Abstract

Recientemente se ha descrito que la leptina presenta actividad hormonal actuando sobre receptores y se ha involucrado con la regulación de la eficiencia metabólica, gasto energético e ingesta alimenticia. Se ha encontrado que es sintetizada en los sincitiotrofoblastos y es secretada dentro de la circulación materna. La leptina ha sido también relacionada con el depósito de grasa. Dado que en el último trimestre del embarazo humano, de manera característica, existe un depósito relativamente aumentado de grasa, y que éste se ve evidentemente depletado en los casos de RCIU, resulta entonces probable que la leptina guarde relación con la entidad. El objetivo de este estudio fue investigar si existen diferencias entre las mediciones de leptina obtenidas en un grupo de pacientes sanas y con RCIU. El estudio fue realizado en 12 pacientes con RCIU (casos) y 9 pacientes sin RCIU (controles). Se tomaron muestras de sangre materna, sangre de cordón y de líquido amniótico (LA). En el estudio pareado (n=9), los niveles de leptina en niños nacidos con RCIU presentaron concentraciones más bajas que los niños control (p = 0.05). Las concentraciones de leptina en sangre de cordón se correlacionaron significativamente con el peso del neonato (p = 0.0002) y peso placentario (p=0.048). No se encontró una correlación estadísticamente significativa de los niveles de leptina en sangre materna con el peso del neonato y el peso placentario. Las concentraciones de líquido amniótico mostraron una correlación inversa y estadísticamente significativa con el peso neonatal (p=0.035), pero no con el peso placentario (p = 0.071). Se observaron correlaciones inversas y estadísticamente significativas entre: concentraciones de leptina materna y leptina en sangre de cordón (p=0.034); leptina de cordón con ...

Perinatal determination of Leptin in mothers and neonates with diagnosis of retard of intra-uterine growth (RCIU) Recently it has been described that the leptin presents hormonal activity, acting on receivers and that it isinvolved in the regulation of the metabolic efficiency, spend energy and nutritious ingestion. Has been synthesizedin the sincitiotrofoblastos and it is secreted inside the maternal circulation. The leptin has also been related in thedeposit of fat. Since in the last trimester of the human pregnancy, in a characteristic way a relatively increaseddeposit of fat exists and that this leaves depletado evidently in the cases of RCIU, it is then probable that theleptin keeps relationship with the entity. The objective of this study was to investigate if differences exist among theleptinmensurations obtained in a group of healthy patients and with RCIU.The study was carried out in 12 patients with RCIU (cases) and 9 patients without RCIU (you control). For such a reason they took samples of maternal blood and blood cord and of amniotic liquid (THE). In the paired study (n=9) the leptin levels in children born with RCIU presented lower concentrations that the children control (p=0.05). The leptin concentrations in blood cord were correlated significantly with the weight of the neonate (p = 0.0002) and I weigh placentario (p = 0.048). It was not to significant correlation statistically of the leptin levels in maternal blood with the weight of the neonate and the placentario weight. The concentrations of amniotic liquid showed an inverse and statistically significant correlation with the weight neonatal (p = 0.035), but not with the placentario weight (p = 0.071). Inverse and statistically significant correlations were observed among: concentrations of maternal leptin and leptin in blood cord (p = 0.034); cord leptin with leptin in liquid amniotic (p = 0.011) and positive correlation between maternal leptin and leptin in the amniotic fluid (p = 0.01).

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http://hemeroteca.unad.edu.co/index.php/nova/article/view/1054/1049
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