Mesenchymal Stem Cells: Biological Characteristics and Clinical Applications

Arévalo Romero, Jenny Andrea; Pardo, Viviana Marcela; Paéz Guerrero, Diana Mercela

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Arévalo Romero, Jenny Andrea

Pardo, Viviana Marcela

Paéz Guerrero, Diana Mercela

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Universidad Colegio Mayor de Cundinamarca

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Abstract

Las células madre mesenquimales son células pluripotentes y adultas con morfología fibroblastoide y plasticidad hacia diversos linajes celulares como condrocitos, osteocitos y adipocitos entre otros. Estas células pueden ser aisladas principalmente de médula ósea, sangre de cordón umbilical y tejido adiposo de donde se han logrado establecer cultivos que han permitido estudiar sus propiedades funcionales y fenotípicas.Aunque la información obtenida hasta la fecha no brinda un conocimiento completo, se espera que con el desarrollo de próximas investigaciones se aclaren diversos aspectos biológicos para implementar su uso en medicina regenerativa. Esta revisión presenta una visión general sobre las células madre mesenquimales: morfología e inmunofenotipo, ontogenia, fuentes de obtención y aplicaciones clínicas.

Mesenchymal stem cells are pluripotent and adult with fibroblastoid morphology and plasticity towards different cell lineages such as chondrocytes, osteocytes, and adipocytes among others. These cells can be isolated mainly from bone marrow, umbilical cord blood, and adipose tissue where it has been possible to establish cultures that have allowed the study of their functional and phenotypic properties.Although the information that has been collected thus far does not offer a complete knowledge, it is hoped that with future research several biological aspects can be cleared up to implement its use in regenerative medicine. This revision presents a general vision of mesenchymal stem cells, morphology and immunophenotype, ontogeny, sources, and clinical applications.

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http://hemeroteca.unad.edu.co/index.php/nova/article/view/387/1167
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Células madre mesenquimales: características biológicas y aplicaciones clínicas.