Modelo Animal de Anemia Inducida por Flebotomía Crónica: Relación Funcional Entre Hierro y Eritropoyesis

Castillo Bohórquez MSC, Martha; D´Anna, María; Gaona Prieto, Suani; García, Betina; Giorgi, Gisela; Mora Bautista MSC, Ana Isabel; Roque, Marta; Villarraga Muñoz, María del Mar

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Castillo Bohórquez MSC, Martha

D´Anna, María

Gaona Prieto, Suani

García, Betina

Giorgi, Gisela

Mora Bautista MSC, Ana Isabel

Roque, Marta

Villarraga Muñoz, María del Mar

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Universidad Colegio Mayor de Cundinamarca

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Abstract

En el presente estudio se analizo la respuesta eritropoyética a la anemia inducida por flebotomía crónica y los cambios en la distribución del hierro celular y sistémico del organismo. Ratones hembra de la cepa CF1 (n=32), se dividieron en dos lotes: control y experimental, siguiendo un diseño experimental pareado según su peso. La distribución del hierro en bazo e hígado durante la flebotomía crónica fue evaluada mediante estudios morfológicos y la actividad eritropoyética mediante estudios hematológicos. Las diferencias estadísticas se determinaron mediante Test Student. El nivel de significancia se fijó en p

In the present work we studied the erythropoietic response to chronic phlebotomy-induced anemia and changes in cellular and systemic body iron distribution. Female mice (CF1 strain, n =32) were divided into control and experimental groups, following a paired experimental design. Iron distribution in spleen and liver during chronic phlebotomy was assessed by morphological studies and erythropoietic activity by hematological studies. Statistical differences were determined by Student test. The significance level was set at p

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http://hemeroteca.unad.edu.co/index.php/nova/article/view/517/994
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