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    Cuantificación de ADN libre en plasma sanguíneo de voluntarios sanos en una población bogotana

    Quantification of free DNA in blood plasma of healthy volunteers in Bogotá population

    Quantification of free DNA in blood plasma of healthy volunteers in Bogotá population

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    Author
    Amaya Guio, Jairo
    Aristizabal Gutiérrez, Fabio Ancizar
    Briceño Balcázar, Ignacio
    Castillo Zamora, Marcos
    García Robayo, Dabeiba Adriana
    Salazar Jordan, Hernán David
    Publisher
    Universidad Colegio Mayor de Cundinamarca

    Citación

           
    TY - GEN T1 - Quantification of free DNA in blood plasma of healthy volunteers in Bogotá population T1 - Cuantificación de ADN libre en plasma sanguíneo de voluntarios sanos en una población bogotana AU - Amaya Guio, Jairo AU - Aristizabal Gutiérrez, Fabio Ancizar AU - Briceño Balcázar, Ignacio AU - Castillo Zamora, Marcos AU - García Robayo, Dabeiba Adriana AU - Salazar Jordan, Hernán David UR - https://repository.unad.edu.co/handle/10596/30119 PB - Universidad Colegio Mayor de Cundinamarca AB - ER - @misc{10596_30119, author = {Amaya Guio Jairo and Aristizabal Gutiérrez Fabio Ancizar and Briceño Balcázar Ignacio and Castillo Zamora Marcos and García Robayo Dabeiba Adriana and Salazar Jordan Hernán David}, title = {Quantification of free DNA in blood plasma of healthy volunteers in Bogotá populationCuantificación de ADN libre en plasma sanguíneo de voluntarios sanos en una población bogotana}, year = {}, abstract = {}, url = {https://repository.unad.edu.co/handle/10596/30119} }RT Generic T1 Quantification of free DNA in blood plasma of healthy volunteers in Bogotá population T1 Cuantificación de ADN libre en plasma sanguíneo de voluntarios sanos en una población bogotana A1 Amaya Guio, Jairo A1 Aristizabal Gutiérrez, Fabio Ancizar A1 Briceño Balcázar, Ignacio A1 Castillo Zamora, Marcos A1 García Robayo, Dabeiba Adriana A1 Salazar Jordan, Hernán David LK https://repository.unad.edu.co/handle/10596/30119 PB Universidad Colegio Mayor de Cundinamarca AB OL Spanish (121)
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    Abstract
    El ADN libre en sangre incrementa con algunas condiciones patológicas y ciertos estados fisiológicos. Varios reportes en la literatura han resaltado que el ADN libre en plasma o suero tiene potencial clínico como una posible herramienta para el pronóstico de cáncer en humanos. Sin embargo, hasta el momento no se tienen valores de referencia de individuos sanos con un tamaño de muestra representativo y tampoco se han descrito valores para poblaciones específicas como la bogotana. Es por ello que en el presente estudio se cuantificó la concentración de ADN libre en personas sanas de la población bogotana y así se estableció un rango normal o valor de referencia, adicionalmente se analizó la relación entre los niveles de ADN libre y las características como edad y género. La concentración de ADN libre en la población bogotana fue de 0,72 ng/μL y no se encontraron diferencias significativas entre las edades y los géneros.
     
    The free DNA in blood increases with some pathological conditions and certain physiological state. Several reports in the literature have highlighted that the free DNA in plasma or serum has clinical potential as a possible tool for the prognosis of human cancer. However, so far there are no reference values of healthy individuals with a representative sample size and no values have been reported for specific populations such as Bogota. That is why in this study we quantified the concentration of free DNA in healthy people of the Bogota population and thus established a normal range or reference value, the relationship between levels of free DNA and characteristics such as age and gender was further analyzed. The concentration of free DNA in the Bogota population was 0.72 ng/μL and no significant differences between ages and genders were found.
     
     
    College
    http://hemeroteca.unad.edu.co/index.php/nova/article/view/427/1119
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    https://repository.unad.edu.co/handle/10596/30119
    URL source
    http://hemeroteca.unad.edu.co/index.php/nova/article/view/427
    http://dx.doi.org/10.22490/24629448.427
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