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    Caenorhabditis elegans como modelo de infección para el estudio de antimicrobianos

    Caenorhabditis elegans as an infection model for the study of antimicrobials

    Caenorhabditis elegans as an infection model for the study of antimicrobials

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    Author
    Rodríguez Morales, Dayana
    Lozano Jiménez, Yenny Yolanda
    Sánchez Mora, Ruth Mélida
    Publisher
    Universidad Colegio Mayor de Cundinamarca

    Citación

           
    TY - GEN T1 - Caenorhabditis elegans as an infection model for the study of antimicrobials T1 - Caenorhabditis elegans como modelo de infección para el estudio de antimicrobianos AU - Rodríguez Morales, Dayana AU - Lozano Jiménez, Yenny Yolanda AU - Sánchez Mora, Ruth Mélida UR - https://repository.unad.edu.co/handle/10596/43051 PB - Universidad Colegio Mayor de Cundinamarca AB - Despite some ethical limitations, animals play an important role as surrogate hosts in investigating the pathophysiological mechanisms of disease in order to test drugs against different pathologies. One of the great problems in public health worldwide in the pharmacological context is the production of antibiotics and the occurrence of microbial resistance, the use of animal models is becoming increasingly complex due to current bioethical restrictions, however, it is necessary to use models simple in preliminary studies that allow evaluating host-pathogen-antimicrobial interactions. Validating that Caenorhabditis elegans is susceptible to various bacteria and also has the ability to respond to environmental stimuli with observable changes in behavior after being fed with various bacteria, it is very useful to use it in this type of research since it has a short average life and does not have ethical restrictions for its use. Therefore, this article reviews the susceptibility of C. elegance to become infected with different bacteria, in addition, since it has not yetbeen fully validated as a model to test antimicrobials, it is proposed that this nematode isuseful as an in vivo model. to evaluate infections and antibacterial treatments. ER - @misc{10596_43051, author = {Rodríguez Morales Dayana and Lozano Jiménez Yenny Yolanda and Sánchez Mora Ruth Mélida}, title = {Caenorhabditis elegans as an infection model for the study of antimicrobialsCaenorhabditis elegans como modelo de infección para el estudio de antimicrobianos}, year = {}, abstract = {Despite some ethical limitations, animals play an important role as surrogate hosts in investigating the pathophysiological mechanisms of disease in order to test drugs against different pathologies. One of the great problems in public health worldwide in the pharmacological context is the production of antibiotics and the occurrence of microbial resistance, the use of animal models is becoming increasingly complex due to current bioethical restrictions, however, it is necessary to use models simple in preliminary studies that allow evaluating host-pathogen-antimicrobial interactions. Validating that Caenorhabditis elegans is susceptible to various bacteria and also has the ability to respond to environmental stimuli with observable changes in behavior after being fed with various bacteria, it is very useful to use it in this type of research since it has a short average life and does not have ethical restrictions for its use. Therefore, this article reviews the susceptibility of C. elegance to become infected with different bacteria, in addition, since it has not yetbeen fully validated as a model to test antimicrobials, it is proposed that this nematode isuseful as an in vivo model. to evaluate infections and antibacterial treatments.}, url = {https://repository.unad.edu.co/handle/10596/43051} }RT Generic T1 Caenorhabditis elegans as an infection model for the study of antimicrobials T1 Caenorhabditis elegans como modelo de infección para el estudio de antimicrobianos A1 Rodríguez Morales, Dayana A1 Lozano Jiménez, Yenny Yolanda A1 Sánchez Mora, Ruth Mélida LK https://repository.unad.edu.co/handle/10596/43051 PB Universidad Colegio Mayor de Cundinamarca AB Despite some ethical limitations, animals play an important role as surrogate hosts in investigating the pathophysiological mechanisms of disease in order to test drugs against different pathologies. One of the great problems in public health worldwide in the pharmacological context is the production of antibiotics and the occurrence of microbial resistance, the use of animal models is becoming increasingly complex due to current bioethical restrictions, however, it is necessary to use models simple in preliminary studies that allow evaluating host-pathogen-antimicrobial interactions. Validating that Caenorhabditis elegans is susceptible to various bacteria and also has the ability to respond to environmental stimuli with observable changes in behavior after being fed with various bacteria, it is very useful to use it in this type of research since it has a short average life and does not have ethical restrictions for its use. Therefore, this article reviews the susceptibility of C. elegance to become infected with different bacteria, in addition, since it has not yetbeen fully validated as a model to test antimicrobials, it is proposed that this nematode isuseful as an in vivo model. to evaluate infections and antibacterial treatments. OL Spanish (121)
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    Abstract
    A pesar de algunas limitaciones éticas, los animales juegan un papel importante como  anfitriones sustitutos para investigar los mecanismos fisiopatológicos de enfermedades con el fin de indagar en ellos medicamentos contra diferentes patologías. Uno de los grandes problemas en salud pública a nivel mundial en el contexto farmacológico es la producción de antibióticos y la ocurrencia de resistencia microbiana, además, cada vez resulta más omplejo el uso de modelos animales por las restricciones bioéticas actuales, no obstante, es necesario usar modelos simples en los estudios preliminares que permitan evaluar las interacciones huésped-patógeno-antimicrobiano. Al validar que Caenorhabditis elegans es susceptible a varias bacterias y además tiene la capacidad de responder a estímulos ambientales con cambios observables en el comportamiento tras ser alimentado con diversas bacterias, resulta muy útil usarlo en este tipo de investigaciones ya que tiene una vida promedio corta y no cuenta con restricciones éticas para su uso. Por lo anterior, en este artículo se revisa la susceptibilidad que tiene C.elegans de infectarse con diferentes bacterias, además, ya que aún no se ha validado completamente como modelo para poner a prueba antimicrobianos se propone que este nematodo es útil como modelo In vivo para evaluar infecciones y tratamientos antibacterianos. 
     
    Despite some ethical limitations, animals play an important role as surrogate hosts in investigating the pathophysiological mechanisms of disease in order to test drugs against different pathologies. One of the great problems in public health worldwide in the pharmacological context is the production of antibiotics and the occurrence of microbial resistance, the use of animal models is becoming increasingly complex due to current bioethical restrictions, however, it is necessary to use models simple in preliminary studies that allow evaluating host-pathogen-antimicrobial interactions. Validating that Caenorhabditis elegans is susceptible to various bacteria and also has the ability to respond to environmental stimuli with observable changes in behavior after being fed with various bacteria, it is very useful to use it in this type of research since it has a short average life and does not have ethical restrictions for its use. Therefore, this article reviews the susceptibility of C. elegance to become infected with different bacteria, in addition, since it has not yetbeen fully validated as a model to test antimicrobials, it is proposed that this nematode isuseful as an in vivo model. to evaluate infections and antibacterial treatments.
     
     
    College
    https://hemeroteca.unad.edu.co/index.php/nova/article/view/5295/5086
    Format
    application/pdf
    Type of digital resource
    info:eu-repo/semantics/article
    info:eu-repo/semantics/publishedVersion
    reviewArticle
    reviewArticle
    reviewArticle
    URI
    https://repository.unad.edu.co/handle/10596/43051
    URL source
    https://hemeroteca.unad.edu.co/index.php/nova/article/view/5295
    10.22490/24629448.5295
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